Cannabidiol promotes browning in 3T3-L1 adipocytes

Obesity and Energy taking or expenditure:

Obesity is the most widely recognized metabolic disease effecting more than 1.4 billion individuals around the world. It has arrived at worldwide plague levels, prompting the development of numerous common medical conditions, for example, cardiovascular disease, diabetes and expanded danger of cancer. 

In obesity development, energy intake exceeds energy expenditure. A particular treatment for obesity should either lessen energy intake, increment energy use, or promote both impacts simultaneously. While decreasing caloric intake is the baseline defense against obesity, it is also critical to modify metabolic efficiency and elevate energy expenditure through key metabolic organs such as adipose tissues and skeletal muscle.

White adipose tissue/White fat(Bad fat): White fat stores energy as large fat droplet(unilocular) and has few mitochondria.

Brown adipose tissue/Brown fat(Good fat): Brown fat has much smaller droplets(multilocular) and particular to consume them, yielding heat. Brown fat cells are fully packed with energy producing powerhouses called mitochondria that contain iron which gives them their brown color and these powerhouses promote lipolysis.

Why do we want to change WAT into BAT?

The significant energy needs of BAT are a result of its special property of heat creation by versatile thermogenesis. This procedure intercedes the breakdown of energy substrates without the generation of ATP. In this way, energy loss by BAT has the ability to control obesity by redirecting abundance fat. WAT has less or no ability like BAT. Therefore, obesity control requires change of WAT into BAT.

What is the cannabidiol(CBD)?

Cannabidiol is an active ingredient derived from cannabis sativa(hemp). It is being studies for its use in pain, anxiety, insomnia, epilepsy, multiple sclerosis, diabetes, bipolar disorders, Crohn’s disease, Parkinson’s disease and recent studies showed that cannabidiol also promotes browning in 3T3L1 adipocytes- which helps in reducing obesity.

How does cannabidiol promotes browning in 3T3-L1 adipocytes or how does it work ?

Molecular evidence showed that thermogenic recruitment of rpWAT occurred following cold exposure but returned to startling levels after cold acclimation-this happens in cold periods for a short amount of time. Cannabidiol causes the same kind of stimulation in WAT(white adipose tissue) and turns on lipolysis, thermogenesis and reduces lipogenesis- this happens by following two ways:

  • Turning white adipocytes into brown adipocytes
  • Activating existing brown adipocytes

If we go through the details – A research was held to combat obesity using CBD, a major non-psychotropic phytocannabinoid of cannabis sativa.

CBD enhanced expression of a core set of brown fat-specific maker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1a) and proteins (UCP1, PRDM16, and PGC-1a).

Expanded expression of UCP1 and other brown fat-explicit markers added to the browning of 3T3-L1 adipocytes potentially through enactment of PPARγ and PI3K. Likewise, CBD expanded protein expression levels of CPT1, ACSL, SIRT1, and PLIN while down-managing JNK2, SREBP1, and LPL. With this information we can see the potential role of CBD in browning of white adipocytes, expansion of lipolysis, thermogenesis, and decrease of lipogenesis. The presented information recommends that CBD assumes double modulatory jobs through inciting the brown like phenotype just as advancing lipid metabolism. In this way, CBD might be investigated as a possibly encouraging restorative operator for the prevention of obesity.




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